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KMID : 0881720090240010038
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Journal of Food Hygiene and Safety
2009 Volume.24 No. 1 p.38 ~ p.45
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Diallyl Disulfide (DADS) Induces Upregulation of PTEN in Human Leukemia Cells
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Chung Weon-Kuu
lee Byoung-Kil
Lee Young-Rae
Park Jinny
Kwon Hyoung-Chul
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Abstract
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The differentiation of leukemia cells into mature cells is a major target of the human leukemia therapy.
As differentiated leukemia cells lose their proliferative and tumor-forming abilities, differentiation inducers may
be useful for the treatment of leukemia. In this study, the experiments were designed to determine whether diallyl disulfide
(DADS) regulates expressions of tumor suppressor protein PTEN (phosphatase and tension homologue) in HL-
60 cells. DADS causes upregulation of PTEN in a time- and dose-dependent manner, which was correlated with
decrease of phospho-Akt level. These results suggest that DADS induces upregulation of PTEN in human leukemia
cells. These results suggest that DADS may be a useful anticancer agent for management of human leukemia.
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KEYWORD
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diallyl disulfide(DADS), PTEN (phosphatase and tension homologue), human leukemia.
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